Vascular integrity studies are essential to understanding therapeutic responses, as blood vessel dysfunction frequently underlies tumour development & progression. While conventional vascular labels are limited by photobleaching, rapid clearance & non-specific leakage from healthy vessels, Vascular Tracker™ 670 enables clear differentiation between intact & compromised states.
In this study, we demonstrate precise visualisation and strong correlation between tumour cluster size & vessel permeability in a cancer model for zebrafish. The solution offers clear advantages over traditional dyes through extended signal longevity, manifested by the synergy of prolonged circulation time with high photostability.
Vascular Tracker 670 is a powerful and promising tool for mapping the tumour microenvironment, particularly in long-term intravital imaging applications & screening anti-angiogenic therapies.
Read the full application note here.